J. William “Bill” Harbour, M.D. Professor & Chair Endowed Title The David Bruton, Jr. Chair in Ophthalmology School Medical School Department Ophthalmology | Harold C. Simmons Comprehensive Cancer Center Graduate Programs Cancer Biology You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography J. William Harbour, M.D., is Professor and Chair of the Department of Ophthalmology at UT Southwestern Medical Center. He specializes in ocular oncology. Dr. Harbour earned his medical degree at Johns Hopkins University and completed a residency in ophthalmology at the Wills Eye Hospital of Thomas Jefferson University. He received advanced training through a fellowship in vitreoretinal diseases and surgery at the Bascom Palmer Eye Institute of the University of Miami, a fellowship in ocular oncology at the University of California, San Francisco, and research training in molecular oncology at Washington University in St. Louis. Certified by the American Board of Ophthalmology, he joined the UT Southwestern faculty in 2021. Previously, Dr. Harbour held the Dr. Mark J. Daily, M.D., Endowed Chair at the Bascom Palmer Eye Institute, where he also served as Director of Ocular Oncology and Vice Chair for Translational Research. He also served as Associate Director for Basic Science at the Sylvester Comprehensive Cancer Center of the University of Miami. Dr. Harbour’s clinical interests focus on ocular tumors such as uveal melanoma, retinoblastoma, and lymphoma. He has trained many residents and fellows and pioneered new surgical methods in fine needle biopsy, laser treatment, and brachytherapy of ocular tumors. He also has been awarded patents for innovations in genetic prognostic testing for uveal melanoma. His research interests include the use of genetic and genomic technologies to better understand, diagnose, and treat eye cancers. His team discovered three of the most important genomic drivers of metastasis in uveal melanoma, as well as key genomic events in retinoblastoma. His contributions to the field have been recognized by the Association for Research in Vision and Ophthalmology’s Cogan Award and the Macula Society’s Paul Henkind and Rosenthal Awards, among many others. Dr. Harbour has delivered more than 300 invited scientific lectures and published more than 200 peer-reviewed scientific articles and book chapters. He is an Associate Editor for Melanoma Research and has served on the editorial boards of Archives of Ophthalmology, Translational Vision Science & Technology, Melanoma Management, Expert Review of Ophthalmology, and Faculty of 1000. Dr. Harbour is a member of numerous professional organizations, including the Association of American Physicians, American Academy of Ophthalmology, American Association for Cancer Research, and American Association of Ophthalmic Oncologists and Pathologists, and he is the founder of the Collaborative Ocular Oncology Group. Education Medical School Johns Hopkins University (1990) Internship Greater Baltimore Medical Center (1991), Internal Medicine Residency Wills Eye Hospital (1994), Ophthalmology Fellowship Bascom Palmer Eye Institute (1995), Retina Fellowship University of California San Francisco (1996), Ocular Oncology Pathology Research Fellowship Washington University School of Medicine (1999), Molecular Oncology Research Interest Genetic mechanisms of metastasis Ocular Oncology Retinoblastoma Tumor Immune Microenvironment Uveal Melanoma Publications Do Short Delays in Treatment Affect Uveal Melanoma Prognosis? Harbour JW, Correa ZM, Stacey AW Ophthalmology 2024 Sep 131 1105-1106 BAP1 is required prenatally for differentiation and maintenance of postnatal murine enteric nervous system Schneider S, Anderson JB, Bradley RP, Beigel K, Wright CM, Maguire BA, Yan G, Taylor DM, Harbour JW, Heuckeroth RO Journal of Clinical Investigation 2024 May 134 PRAME induces genomic instability in uveal melanoma Kurtenbach S, Sanchez MI, Kuznetsoff J, Rodriguez DA, Weich N, Dollar JJ, Cruz A, Kurtenbach S, Field MG, Durante MA, Decatur C, Sorouri M, Lai F, Yenisehirli G, Fang B, Shiekhattar R, Pelaez D, Correa ZM, Verdun RE, Harbour JW Oncogene 2024 Feb 43 555-565 Vitreous metastasis from cutaneous melanoma: diagnosis and management Ashkenazy N, Harbour JW, Dubovy SR, Albini TA, Sridhar J, Patel N, Hansen ED, Uchiyama E, Rubsamen PE, Correa ZM Arquivos Brasileiros de Oftalmologia 2024 87 Correction: Activation of NFAT by HGF and IGF-1 via ARF6 and its effector ASAP1 promotes uveal melanoma metastasis (Oncogene, (2023), 42, 35, (2629-2640), 10.1038/s41388-023-02792-6) Richards JR, Shin D, Pryor R, Sorensen LK, Sun Z, So WM, Park G, Wolff R, Truong A, McMahon M, Grossmann AH, Harbour JW, Zhu W, Odelberg SJ, Yoo JH Oncogene 2023 Sep 42 3015 Activation of NFAT by HGF and IGF-1 via ARF6 and its effector ASAP1 promotes uveal melanoma metastasis Richards JR, Shin D, Pryor R, Sorensen LK, Sun Z, So WM, Park G, Wolff R, Truong A, McMahon M, Grossmann AH, Harbour JW, Zhu W, Odelberg SJ, Yoo JH Oncogene 2023 Aug 42 2629-2640 Co-Targeting FASN and mTOR Suppresses Uveal Melanoma Growth Han A, Mukha D, Chua V, Purwin TJ, Tiago M, Modasia B, Baqai U, Aumiller JL, Bechtel N, Hunter E, Danielson M, Terai M, Wedegaertner PB, Sato T, Landreville S, Davies MA, Kurtenbach S, Harbour JW, Schug ZT, Aplin AE Cancers 2023 Jul 15 IRIS METASTASIS from BREAST CANCER SUCCESSFULLY TREATED with ABEMACICLIB and LETROZOLE Goduni L, Ashkenazy N, Hansen E, Soyano-Muller A, Correa ZM, Harbour JW Retinal Cases and Brief Reports 2023 Mar 17 123-125 Advances in the clinical management of uveal melanoma Carvajal RD, Sacco JJ, Jager MJ, Eschelman DJ, Olofsson Bagge R, Harbour JW, Chieng ND, Patel SP, Joshua AM, Piperno-Neumann S Nature Reviews Clinical Oncology 2023 Feb 20 99-115 Post-Radiation Cataract Management: Outcomes in Individuals with Uveal Melanoma Sepulveda-Beltran PA, Levine H, Gibbons AG, Maharaj A, Choi DS, Martinez JD, Correa ZM, Amescua G, Harbour JW Current Ophthalmology Reports 2022 Dec 10 218-227 Results 1-10 of 251 1 2 3 4 5 Next Last Books Featured Books Cellular and Genetic Events in Retinal Tumorigenesis. In Clinical Ocular Oncology, 2nd Edition Dyer MA, Harbour JW (2014). Elsevier Intraocular Lymphoma. In Albert and Jakobiec's Principles and Practice of Ophthalmology, 4th Edition Echegaray JJ, Harbour JW (2021). Springer Choroidal Nevus and Melanocytoma. In Albert and Jakobiec's Principles and Practice of Ophthalmology, 4th Edition Alhumaid S, Harbour JW (2020). Springer Intraocular Lymphoma. In Albert and Jakobiec's Principles and Practice of Ophthalmology, 4th Edition Echegaray JJ, Harbour JW (2020). Springer Intraocular Lymphoma. In The Retina Illustrated, 2nd Edition Paez-Escamilla M, Andreoli M, Harbour JW (2019). Thieme Publishers Initial management of uveal and conjunctival melanomas. In UpToDate (https://www.uptodate.com/contents/initial-management-of-uveal-and-conjunctival-melanomas?csi=6b3b6b40-70aa-4e13-b4f3-20d893aa7f57&source=contentShare#H4241265126) Harbour JW, Shih HA (2018). Intraocular Lymphoma: A Clinical Approach. In The Retina Illustrated, 1st Edition Paez-Escamilla M, Andreoli M, Harbour JW (2018). Thieme Publishers Genomics and Precision Medicine in the Management of Ocular Tumors. In Vitreoretinal Surgical Techniques, 3rd Edition Paez-Escamilla M, Walter S, Harbour JW (2018). CRC Press Uveal Melanoma. In Encyclopedia of Cancer, 4th Edition Ehlers JP, Harbour JW (2017). Berlin Heidelberg, Springer-Verlag Retinoblastoma: Clinical and Molecular Perspectives. In The Molecular Basis of Human Cancer, 2nd Edition Harbour JW, Walter SD (2015). Springer Molecular Biology of Retinoblastoma. In Recent Advances in Retinoblastoma Treatment Walter SD, Harbour JW (2015). Springer Second Primary Tumors in Retinoblastoma. In Orbital Tumors: Diagnosis and Treatment, 2nd Edition Harbour JW. Mohsenin A (2014). Springer Cancer Genetics. In Clinical Ocular Oncology 2nd Edition Harbour JW, Chao DL (2013). Springer Honors & Awards Alcon Research Institute Basic Sciences Award (2016-2017) Retina Research Foundation/Kayser Global Award (2015) ARVO Silver Fellow (2014) Macula Society Paul Henkind Memorial Award and Lecture (2014) RPB Senior Scientific Investigator Award (2014-2017) ASRS Honor Award (2013) Shaler Richardson, MD Service to Medicine AwardFlorida Society of Ophthalmology (for personal contribution to quality patient care by collaborating and integrating ophthalmology into the medical profession on a national level) (2013) AAO Senior Achievement Award (2012) Ocular Melanoma Foundation Research Award (2011) Macula Society Rosenthal Award (2008) ARVO Cogan Award (2005) RPB David F. Weeks Professorship in Translational Research Award (2005-2006) AAO Achievement Award (2003) RPB Physician-Scientist Award (2002-2003) RPB Career Development Award (1996-1999) Heed-Knapp Ophthalmic FellowshipUC San Francisco (1995-1996) Heed Ophthalmic Foundation FellowshipBascom Palmer Eye Institute (1994-1995) Professional Associations/Affiliations American Academy of Ophthalmology (1991) American Association for Cancer Research (1996) American Association of Ophthalmic Oncologists & Pathologists (2000) American Ophthalmological Society (2014) American Society of Retina Specialists (1996) Association for Research in Vision and Ophthalmology (1992) Association of American Physicians (2010) Collaborative Ocular Oncology Group (2007) International Society of Ocular Oncology (1998) Macula Society (1999) Retina Society (1998) Society for Melanoma Research (2010) Society of Heed Fellows (1996)
